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Publication
Department of Chemitry
International Journal
| Genes (Basel) | |
|---|---|
| 년도 | 2018 |
| 학술지명 | Genes (Basel) |
| 논문명 | Understanding the Role of the BAI Subfamily of Adhesion G Protein-Coupled Receptors (GPCRs) in Pathological and Physiological Conditions. |
| 게재권/집 | |
| 수록페이지 | |
| 저자명 | Moon SY, Shin SA, Oh YS, Park HH, & Lee CS |
Abstract Brain-specific angiogenesis inhibitors (BAIs) 1, 2, and 3 are members of the adhesion G protein-coupled receptors, subfamily B, which share a conserved seven-transmembrane structure and an N-terminal extracellular domain. In cell- and animal-based studies, these receptors have been shown to play diverse roles under physiological and pathological conditions. BAI1 is an engulfment receptor and performs major functions in apoptotic-cell clearance and interacts (as a pattern recognition receptor) with pathogen components. BAI1 and -3 also participate in myoblast fusion. Furthermore, BAI1⁻3 have been linked to tumor progression and neurological diseases. In this review, we summarize the current understanding of the functions of BAI1⁻3 in pathological and physiological conditions and discuss future directions in terms of the importance of BAIs as pharmacological targets in diseases. Keywords: apoptotic cell clearance; brain-specific angiogenesis inhibitor; engulfment; tumorigenesis |
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