Cell Reports > International Journal

Cell Reports
년도	2024
학술지명	Cell Reports
논문명	Maladaptation of dentate gyrus mossy cells mediates contextual discrimination deficit after traumatic stress
게재권/집
수록페이지
저자명	Minseok Jeong, Jin-Hyeok Jang, Seo-Jin Oh, Jeongrak Park, Junseop Lee, Sehyeon Hwang, Yong-Seok Oh
Link	https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00328-0 2721회 연결
Summary Fear overgeneralization is a maladaptive response to traumatic stress that is associated with the inability to discriminate between threat and safety contexts, a hallmark feature of post-traumatic stress disorder (PTSD). However, the neural mechanisms underlying this deficit remain unclear. Here, we show that traumatic stress exposure impairs contextual discrimination between threat and safety contexts in the learned helplessness (LH) model. Mossy cells (MCs) in the dorsal hippocampus are suppressed in response to traumatic stress. Bidirectional manipulation of MC activity in the LH model reveals that MC inhibition is causally linked to impaired contextual discrimination. Mechanistically, MC inhibition increases the number of active granule cells in a given context, significantly overlapping context-specific ensembles. Our study demonstrates that maladaptive inhibition of MCs after traumatic stress is a substantial mechanism underlying fear overgeneralization with contextual discrimination deficit, suggesting a potential therapeutic target for cognitive symptoms of PTSD.

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