Frontiers in Oncology > International Journal

Frontiers in Oncology
년도	2019
학술지명	Frontiers in Oncology
논문명	Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression
게재권/집	vol.9/ Article Number571
수록페이지
저자명	Kim Hyun Jung, Lee Sukmook, Oh Yong-Seok, Chang Ha Kyun, Kim Young Sang, Hong Sung Hee, Kim Jung Yong, Park Young-Whan, Lee Song-Jae, Song Seong-Won, Kim Jung Ju, Heo Kyun
Link	https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.20… 5075회 연결
Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF) is important in ovarian cancer cell migration and invasion. This study assessed the effects of YYB-101, a humanized monoclonal anti-HGF antibody, on the growth and metastasis of ovarian cancer cells. YYB-101 suppressed the phosphorylation of the HGF receptor c-MET and inhibited the migration and invasion of SKOV3 and A2780 ovarian cancer cells. Moreover, the combination of YYB-101 and paclitaxel synergistically inhibited tumor growth in an in vivo ovarian cancer mouse xenograft model and significantly increased the overall survival (OS) rate compared with either paclitaxel or YYB-101 alone. Taken together, these findings suggest that YYB-101 has therapeutic potential in ovarian cancer when combined with conventional chemotherapy agents.

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