Cytokine > International Journal

Cytokine
년도	2018
학술지명	Cytokine
논문명	Interleukin-5 suppresses Vascular Endothelial Growth Factor-induced angiogenesis through STAT5 signaling
게재권/집	vol.110 /397-403
수록페이지
저자명	Bucher Felicitas, Lee Jungho, Shin Sanghee, Kim Minseok , Oh Yong-Seok, Ha Sanghoon, Zhang Hongkai, Yea Kyungmoo
Link	https://www.sciencedirect.com/science/article/abs/pii/S104346661830270… 4034회 연결
Abstract Interleukin-5 (IL-5) is best known as key regulator in eosinophil-associated diseases such as asthma. While a connection to vascular changes in eosinophil-associated lung diseases is still elusive, recent evidence suggests that IL-5 may have an atheroprotective role. Here, we report an unexpected anti-angiogenic potential of IL-5 on vascular endothelial cells in vitro. IL-5 significantly inhibited fundamental functions of human lung microvascular endothelial cells (HMVEC-L) in vessel formation including VEGF-induced endothelial cell proliferation, migration and tube formation. Knockdown (KD) of STAT5 abolished the direct anti-angiogenic effect of IL-5 on VEGF-induced endothelial cell proliferation, migration and tube formation.

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